3 edition of Genetic Instability and Tumorigenesis (Current Topics in Microbiology and Immunology) found in the catalog.
by Springer-Verlag Telos
Written in English
|The Physical Object|
|Number of Pages||180|
In , Fearon and Vogelstein [ 24] published the multistep model of colon tumorigenesis in which they proposed that tumors develop as the result of mutational activation of oncogenes coupled with the mutational inactivation of tumor suppressor genes. Most scientists agree that the majority of human solid malignant tumors are characterized by chromosomal instability (CIN) involving gain or loss of whole chromosomes or fractions of chromosomes. CIN is thought to be an early event during tumorigenesis and might therefore be involved in tumor initiation. Despite its frequent occurrence in tumors and its potential .
Genetic instability and the development of recurrence of primary tumor and second primary tumor during head and neck tumorigenesis. Research output: Contribution to journal › Article N. Charuruks, D. M. Shin, N. Voravud, Jae Ro, W. K. Hong, W. N. Hittelman. Cheryl Jacobs, Ying Huang, Tehmina Masud, William Lu, Gerwin Westfield, William Giblin and JoAnn M. Sekiguchi, A hypomorphic Artemis human disease allele causes aberrant chromosomal rearrangements and tumorigenesis, Human Molecular Genetics, 20, 4, (), ().
Genetic instability is one of the common characteristics of colorectal cancer. Three major types of genetic instability have been reported in colorectal cancer [7–10].Microsatellite instability occurs due to variations in DNA mismatch repair genes, while chromosomal instability (CIN) is distinguished by major chromosomal alterations occurring at cell division and usually involves . T1 - Genome instability. T2 - Does genetic diversity amplification drive tumorigenesis? AU - Lane, Andrew B. AU - Clarke, Duncan J. PY - /11/1. Y1 - /11/1. N2 - Recent data show that catastrophic events during one cell cycle can cause massive genome damage producing viable clones with unstable genomes.
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This book reviews our current level of understanding of the role of genetic instability in human tumorigenesis. In this most rapidly moving field, discoveries in recent years have elucidated a number of important gene products which control cellular responses to DNA damaging agents, e.g., DNA repair and cell cycle by: M.
KASTAN Cancer is a disease resulting from alterations of cellular genes which cause phe notypic changes in somatic cells. Usually, when we think about genetic diseases, we think about inheriting one or two abnormal genes from our parents.
KASTAN Cancer is a disease resulting from alterations of cellular genes which cause phe notypic changes in somatic cells. Usually, when we think about genetic diseases, we think about inheriting one or two abnormal genes from our parents and these gene abnormalities confer the disease phenotype.
This book reviews our current level of understanding of the role of genetic instability in human tumorgenesis. In this incredibly rapidly moving field, discoveries in recent years have elucidated a number of important gene products which control cellular responses to DNA damaging agents, such as DNA repair and cell cycle perturbations.
This volume reviews the level of understanding of the role of genetic instability in human tumourigenesis. It covers a range of topics from scientific insights into genetic instability learned from simple model systems, eg, yeast, to the genes.
Kastan M.B. () Genetic Instability and Tumorigenesis: Introduction. In: Kastan M.B. (eds) Genetic Instability and Tumorigenesis. Current Topics in.
English, Book, Illustrated edition: Genetic instability and tumorigenesis / edited by M. Kastan. Kastan, M. (Michael B.). Chromosomal instability and tumorigenesis: genetic analysis of the murine spindle checkpoint gene Mps1.
Author(s) Xie, Stephanie Zhi-Juan. DownloadFull printable version (Mb) Alternative title. CIN and tumorigenesis: genetic analysis of the. Cellular transformation and the accumulation of genomic instability are the two key events required for tumorigenesis.
K-Ras (Kirsten-rat sarcoma viral oncogene homolog) is a prominent oncogene. Email your librarian or administrator to recommend adding this book to your organisation's collection.
Systems Biology of Cancer. Evidence that genetic instability occurs at an early stage of colorectal tumorigenesis. Cancer Res – A genetic model for colorectal tumorigenesis. Cell – Vogelstein B.
Genome Instability. (see the corresponding chapters in this book). In contrast, genome instability covers a broad range of topics referring to an increased rate of DNA damage and the associated mutations, is well defined in inherited cancers owing to the established relationship between mutations in DNA-repair genes and tumorigenesis.
It also describes genetic instability and the generation of metastatic variants. The chapter elaborates in detail about DNA repair and repair fidelity in metastatic variants. The chapter concludes with a discussion on telomerase function, genetic instability, cell proliferation, and cancer metastasis.
Tumorigenesis can be viewed as an imbalance between the mechanisms of cell-cycle control and mutation rates within the genes. Genomic instability is broadly classified into microsatellite instability (MIN) associated with mutator phenotype, and chromosome instability (CIN) recognized by gross chromosomal abnormalities.
DNA Repair, Genetic Instability, and Cancer 1st Edition by Qingyi Wei (Editor), Lei Li (Editor), David J Chen (Editor) & ISBN ISBN Why is ISBN important. ISBN. This bar-code number lets you verify that you're getting exactly the right version or edition of a book. The digit and digit formats both work.
However, we have started to comprehend their causative link to tumorigenesis only recently. Chromosomal instability – as a process leading to abnormal chromosome content and heterogeneity – has been widely researched and increasingly referred to as driving force behind malignant transformation and defining factor for cancer evolution.
Thus, HR plays pivotal roles in maintaining genome stability and preventing tumorigenesis. Although HR is generally an error-free DNA repair process, hyper-recombination, hypo-recombination and altered HR outcomes can all lead to genomic instability.
Thus HR can be mutagenic and contribute to genomic instability when it is not properly regulated. Genetic instability and tumorigenesis: introduction. Published. Journal Article. Full Text. Published version (via Digital Object Identifier) Pubmed Central version; Link to Item; Duke Authors.
Kastan, Michael Barry; Cited Authors. Kastan, MB Published Date. Published In. Current Topics in Microbiology and Immunology Volume / Issue. A major question in cancer genetics is to what extent CIN, or any genetic instability, is an early event and thus a driving force in tumorigenesis [41–47].
Here, we discuss mathemat-ical models that investigate the role of CIN in cancers which require elimination of one or two TSGs [42,46–48].
Chromosomal instability before one tumor. to determine whether genetic instability is associated with mammary tumorigenesis in vivo in the absence of heritable defects in known DNA maintenance genes. Materials and Methods Escherichia coliStrains. The E. coli host strain G (Stratagene) used in this study, which carries mutant hflA and hflB genes that.
Together with genetic analyses, including a genome-wide assessment of allelic imbalances, our data indicate that early in tumorigenesis (before genomic instability and malignant conversion), human. Keywords: Genetic instability, tumorigenesis, oncogenes, tumor suppressor genes, DNA replication, cell replication, replication unbalance, chromosomal instability Introduction Acquisition of the multiple characteristics of cancer cells depends to a large extent on the accumulation of alterations in their genomes [ 1 ].The book shows how mathematical and computational models can be used to study cancer biology.
It introduces the concept of mathematical modeling and then applies it to a variety of topics in cancer biology. These include aspects of cancer initiation and progression, such as the somatic evolution of cells, genetic instability, and angiogenesis.Evidence That Genetic Instability Occurs at an Early Stage of Colorectal Tumorigenesis 1 Ie-Ming Shih, Wei Zhou, Steven N.
Goodman, Christoph Lengauer, Kenneth W. .